Selenium

January 30th, 2023

Selenium: a trace mineral found in some foods and the earth.

A mineral primarily necessary as a cofactor in cellular reactions related to reproduction, hormone synthesis, DNA synthesis and immune function. It specifically helps protect against toxic oxygen radicals and oxidative damage.

I love selenium because it helps to recycle the most important antioxidant/chemical clearance molecule that we have called glutathione. Without adequate selenium, glutathione levels will drop and you will be much more prone to xenobiotic chemical damage from our chemically polluted world.

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Treating disease upstream!

 January 30th, 2023

Marty Makary has a video that tackles this reality. Link

This is the truth of the problem. Why are we treating diabetes with insulin only? Where are the cooking classes, access to healthy food, counseling and therapy to reduce the psychological concerns leading to eating dysfunction???? The cost of prevention is always less that later treatment. Not to mention that preventative education leads to improved healthspan and lifespan.

 Our societal, medical and governmental focus is upside down as it relates to chronic disease.

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Coronavirus Update 80 plus other stuff

January 30th, 2023

 

We are months into a highly infectious Omicron wave with new strains XBB/.1.5 supplanting BA.4/5 with absolutely no signs of worsening disease severity or morbidity. The country as a whole is in the best place since the pandemic began and then became an endemic state. For most Americans, we are dealing with mild disease only. Severity and poor outcomes remains in the at risk groups despite the CDC not releasing

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Amazing Rowan County Community

January 23rd, 2023

It is amazing how beautiful the world can be when we work for the greater good. One of our care coordinators began a process to help a family in acute need and voila, the people respond. I wanted to share a story of love to lighten the hearts of all. Give where you can today to give someone a brighter day!

"Hey Everyone,

I just wanted to let everyone know about the amazing community that Rowan County is. One of our families (a mom and 3 kids we see here) was displaced by a fire late last week. They lost everything.

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Aging is now firmly proven to be an epigenetic phenomenon, in mice!

January 23rd, 2023

From the David Sinclair Lab at Harvard we see first of its kind data regarding the ability to identify epigenetic marks in mice as the etiology or biomarker of aging. This is nothing short of an amazing discovery. Listen to Podcast #2 with the father of epigenetics Dr. Randy Jirtle to gain a foothold in this world and then read on.

From the article: "All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of chromatin-modifying proteins to DNA breaks,

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An Opinion on Obesity With approval from Dr. Katz to publish in its entirety as written in Linked In this past week.

 

 January 23rd,2023

"I imagine -and in select cases know- that many of my colleagues were encouraged and gratified to hear that the NIH is allocating a sizable sum to the pursuit of precision nutrition. Some number of my colleagues will be directly involved in those research efforts, and others are simply pleased to see nutrition getting some small measure of the attention we agree it warrants. I can appreciate these reactions, but in my case, the response felt more like a wave of nausea accompanied by echoes of “here we go again, again.”

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Pathophysiology Redo for those that missed it and need a refresher on how to stay safe with Omicron XBB.1.5 on the Prowl!

January 16th, 2023

A massive piece of the pathophysiology story resides in precursor risk factors for poor pathogen clearance and worsened inflammatory responses. Epidemiologically, it is very clear that 95% or more of the COVID related deaths were in groups that had either advanced age and/or comorbid diseases related to poor lifestyle choices as the standard American diet, sedentary behavior, toxin exposure, eating excessive calories, inadequate sleep, mental stress and other issues all drive dysfunctional shifts in T helper cell activity, autoantibody production and systemic inflammation. These changes are present in the host prior to infectious viral exposure setting the stage for poor viral surveillance, killing capacity and later hyper inflammation.

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Volume 13, Letter 5 Coronavirus Update 79 plus other stuff

 

January 16th, 2023

This week we look at new data on viral cell infiltration, mask efficacy, hyperlipidemia, micro and macronutrient metabolism post moderate to severe disease and then we switch over to random acts of kindness and then onto social media use and outcomes in teens.

 Omicron US strains: as of January 14th data - variants make up:

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Obesity Treatment for Adolescents

January 9th, 2023

Semaglutide is a new injectable drug that has shown incredible results in adults with diabetes and obesity by activating the glucagon like peptide one receptor. This action increases insulin release, glycemic control and blood glucose utilization. This in effect decreases adipose storage and blood glucose increases that lead to the symptoms of diabetes over time.

Before I discuss the study, I want to point out that this medicine is 100% unnecessary if children and adolescents follow a healthy diet and exercise regimen.

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Potassium

 January 9th, 2023

Potassium: a mineral found abundantly in some foods and the earth as a white salt. It gets its name from potash or plant ash which is loaded with potassium.

Every cell in the body utilizes potassium in some way. It is necessary for signal transduction in all nerves and muscles including the heart. It is critical for kidney and hormone function. Your intestines require it to move and your blood requires it to keep acid/base balance. We use it in carbohydrate metabolism and much more.

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Literature Review

January 9th, 2023 

Memories can be laid down well without sleep attached to it according to a new study in PNAS. It has long been said that sleep is key to culling neurons that are related to memories that are unimportant and also increasing the quality of the neurons for memories that we need to keep, while sleep deprivation disrupts this reality. The authors of this study looked at two groups of rats show a novel object and tracked the quality of the memory formation. They state: "Long-term memories are considered to be optimally formed during sleep, but they may also be formed during wakefulness. Using behavioral indicators dissociating object and context memory in a novel-object recognition (NOR) paradigm, in combination with pharmacological inhibition of hippocampal activity

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Iron: Fourth on my list of imprortant minerals. Could be first actually!

 

January 2nd 2023

A mineral primarily necessary for carrying oxygen around our body via hemoglobin proteins on our red blood cells. It is also found in a storage form called ferritin in our liver, spleen and bone marrow or as myoglobin in our muscles.

It is critical for the function of oxygen transport, muscle metabolism, neurologic and intracellular signal transmission. It is also critical for hormone function growth and development. Iron is critical to learning and developing as a baby/toddler. Iron is used by white blood cells as well as microbes in metabolism

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Omicron US strains: as of December 24th data - variants make up: BA.4.6 is 1%, BF.7 is 4%, BA.5 is 7%, BQ.1 is 27%, BQ1.1 is 36% - New strains XBB is 18% and BN.1 is 4%

Decmeber 2nd, 2022

None of these VOC's are showing signs of increased disease morbidity.

 

Little else to report here. (CDC Variants)

 Quick Hits and other musings -

1) Boring week - nothing to report this week on covid!

2) Science heavy but an explanation for certain humans that struggle with weight gain: "Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity. The mutation places ASIP under control of the ubiquitously active itchy E3 ubiquitin protein ligase promoter, driving the generation of ASIP in patient-derived native and induced pluripotent stem cells for all germ layers and hypothalamic-like neurons.

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Loneliness

 

December 26th, 2022

Humans like many animal species like to live or interact in groups. The species in general has historically benefited from collective grouping behaviors. Safety in numbers and shared food collection has allowed humans to live and thrive. Human groupings are like social concentric circles with country at the large end and family unit at the small end. It is at the extended family sized ring that people really benefit from psychologically through intimate love, education of values and elder wisdom and perceived safety.

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Calcium

December 26th, 2022

A mineral involved in many reactions in the body! It is found primarily in our bones and teeth as a storage site. The body carefully regulates calcium levels by stealing from the bones when the system needs more.

It is critical for the function of blood vessels, muscles, neurologic and intracellular signal transmission. It is also critical for hormone secretion. This covers every aspect of feeling good and moving with fluidity.

Based on age, we need roughly 1000 mg daily. This should be derived primarily through food. If you need to supplement, current evidence suggests that supplementing above 500mg for a 70 kg human is not a good idea.

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Food in Infants What do we know?  

 December 26th, 2022

"Humans are the only mammals who feed our young special complementary foods before weaning and we are the only primates that wean our young before they can forage independently. There appears to be a sensitive period in the first several months of life when infants readily accept a wide variety of tastes and this period overlaps with a critical window for oral tolerance. As a result, infants should be exposed to a wide variety of flavors while mother is pregnant, while mother is nursing and beginning at an early age. There also appears to be a sensitive period between 4 and 9 months when infants are most receptive to different food textures.

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Limitless

December 19th, 2022

The new docu-series on National Geographic Disney with Chris Hemsworth is excellent.

Many of the topics discussed here over the years are explored visually for us all to consume over a few episodes. Chris is challenged to push himself beyond his previous limits and beliefs. Where this series takes a turn for the best is the linkage to health and longevity. They explore how pushing oneself to discomfort is actually health promoting longe term. The science is discussed in parallel to the challenge and the mental/physical drama.

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Omicron US strains: as of December 17th data - variants make up: BA.4.6 is 1%, BF.7 is 5%, BA.5 is 10%, BQ.1 is 31%, BQ1.1 is 38% - New strains XBB is 7% and BN.1 is 4%

December 19th, 2022

The new world of Omicron is a constant deck chair shuffle regarding which strain holds court and for how long. It appears that a few months is the max a strain maintains the chairs. China is heading into a massive illness burden which could alter the frequency of the mutations.

None of these VOC's are showing signs of increased disease morbidity.

Little else to report here. (CDC Variants)

 Quick Hits and other musings -

1) More on vaccines in young adults men from JAMA: "Question What are the frequency, clinical features, and early outcomes associated with myopericarditis after COVID-19 mRNA vaccination in adolescents and young adults? Findings: In this systematic review and meta-analysis of 23 studies, including 854 patients aged 12 to 20 years with vaccine-associated myopericarditis, the incidence of myopericarditis was higher in males after the second dose.

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Long Distance Love bombs

December 12th, 2022

What are they?

According to Dr. Jeremy Goldberg, they are acts of verbal and written kindness sent out to the masses for the stated purpose of promoting and growing kindness and happiness. Don't you just love that!

I do.

For that reason, I am interviewing him this week for the podcast to really dive deep into the reasoning of word choice, the effects of that choice in relationship and how anger bludgeons this process.

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Zinc 2

December 12th, 2022

 

Zinc is the second most abundant mineral on earth after Iron and is critical for many biological processes. Zinc exists in a 2+ state and is not sensitive to redox reactions making it an ideal cofactor for enzymatic activity of cells that turn over rapidly like skin, gut and immune cells. For this reason it is used often in the cell and needs to be provided in adequate volume for normal function.

Zinc must be actively transported into the cell for action to occur leaving humans needing zinc transporters for optimal function.

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