Omicron Overview - The world of omicron as I see it now

January 17th, 2022

Ugh - 2 weeks changes everything

My partner, Dr. Koontz stated the other day, that nature is vaccinating the US with Omicron since we couldn't do it. He was present during measles outbreaks in Dallas, Texas during his training and he noted this feels closer to that than anything in his career. He is correct. Everyone will see this virus sooner or later this year. Hopefully, since we cannot vaccinate this virus into submission like measles, this will become like seasonal influenza where we have some a priori immunity leading to less death. Fingers crossed.

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Vaccine Effectiveness Goes Down The Drain

January 17th, 2022

By Viany Prasad

"Some argue there is still a justification to boost because you can help prevent hospitals from being overwhelmed. Sadly, that argument fails in several ways. First, you have no evidence boosting younger people will slow hospitalizations. A vaccinated younger person already has very low risk of being hospitalized. Boosting may not further lower what is already very low. We simply have no evidence. Event rates are sparse at those ages.

Second, this argument would mean the state could tell people what to eat and how much to exercise, and how much to drink.

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COVID Pathophysiology 2021/2022

 January 17th, 2022

 

The massive update to this theory is finished for now: it is long, complex and interesting!

SARS2, the virus that causes Covid – 19, is now known to be an infectious disease with features of a human disease that span the spectrum from asymptomatic to profoundly dysregulated immune system responses leading to both aggressive inflammation and autoimmunity in the moderately to severely affected persons. It is now very clear that the vast majority of these significantly affected

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Fructose redo

 Januray 24th, 2022

 In preparation for the upcoming podcast with Dr. Rick Johnson. We are going to discuss the survival switch and fructose metabolism in specific. It will be another life changing discussion for many of us.


We all are paying more attention to the effects of lifestyle choices on our health especially as it relates to Covid 19. One of the primary lifestyle choices that is hurting us is the over consumption of refined carbohydrates or sugars, in particular the molecule fructose.

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2 COMPLETELY AVOIDABLE DISEASES OF CHILDHOOD

january 24th, 2022

Redo
Non Alcoholic Fatty Liver Disease, NAFLD

Non Alcoholic Steatohepatitis, NASH

When I was in medical school in the early 90's, the primary cause of fatty liver disease in adults was alcohol abuse. Over the last 20 years, the obesity epidemic and associated fatty liver disease, NAFLD, has taken over first place. Unfortunately, this is no longer an adult only phenomena. Akin to type II diabetes mellitus, children are now suffering increasing rates of NASH and then NAFLD.

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  Volume 11, Letter 36 Vision and Breathing

 August 23rd, 2021

Poll questions

Do you praise effort more than ability?

100% said yes. that is great news for our kids!

Do you let your kids conflict resolve without intervention?

65% said yes

 Vision and Breathing

What are the connections between breathing and vision?

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23 and Me

September 27th, 2021

23 and Me has been working hard behind the scenes to obtain some solid scientific genetic evidence behind COVID risk.

In two studies published in MedRxIV over the past year, we see evidence based on over 1,000,000 gene analysis that blood type, ethnicity and metabolic risk factors are associated with a worse outcome. Blood group O is protective while A, as discussed in other studies, may be deleterious for health. The mechanism behind this effect is still up for debate.

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Volume 11, Letter 42

 

 October 4th, 2021

One of my favorite podcasts was just launched yesterday with Dr. David Rakel. We discuss stress and maternal happiness. It is a joyous conversation as Dave is a fabulous speaker and even better teacher. There are few people in the world with his combined skill set. I have added some music to the podcast as an intro, still need to figure out how to do a voice over. Rookie contract still in effect it seems!

I hope that you join me and listen to Dr. David Rakel.

Apple Podcast
Amazon Music

 

 

Stress Psychiatry and the Intestinal Microbiome

 October 4th, 2021

Over a few upcoming podcasts we are going to take a deep dive with a few experts in the gut health space. In preparation for these discussions, I am going to highlight some of the literature on the related issues like this week:

Humans develop disease from many different routes including toxic exposures, genetics, poor nutrition, injury, microbial exposures and much more. One of the biggest risk factors for the development of disease is mental stress. Specifically, chronic stress of the psyche is traumatic to the cellular machinery of the body like the protective telomere tails of DNA strands or the functioning intestinal microbiome.

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A new and interesting book is out: How to raise kids who aren't assholes!

October 4th, 2021

Raising kids is a mix of art and science and likely always will be. In this new book, Melinda Moyer looks at the science side of the equation.

The author writes: "One of the core questions I had was, “How do I raise my kids to be generous and kind?” A lot of what we hear is about the importance of teaching giving and generosity. But the research I kept coming across stemmed from how we talk about feelings. That’s surprising—why would that have anything to do with how generous children would become?

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It came to me this Morning

As I was sitting outside on the back porch thinking this morning, I came across a memory that meant a lot to me and also predicts a child's outcome to some extent. I once told the story of my childhood musical decision in 3rd grade. My parents ushered me into a large gymnasium at Hagan Elementary School littered with every instrument from the ukulele at one end to the xylophone at the other. When my siblings made the same walk of choice, they chose the violin and the flute respectively.

Then there was little old scrawny 8 year old me. I passed with a huge smile on my face every instrument. "this one?" my father would say. "How about this one?"

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  Volume 11, Letter 43 Coronavirus Update 46

 October 11th, 2021

The 4th wave is over in North Carolina.

If you have had 2 doses of an mRNA vaccine, you have a very very small risk of a significant hospitalization and almost no chance of death from the Delta variant based on statistics overall.

Being Unvaccinated now is the greatest risk factor for a negative outcome. Advancing age and co morbid disease add layers of risk on top of the vaccination status

Latest numbers google/CDC

We are continuing to see that the lambda, gamma and mu variants are not an issue yet and likely will not be in the United States as delta is outcompeting them.

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Emulsifiers

October 18th, 2021

From the Food and Drug Administration: There are thousands of ingredients used to make foods. The Food and Drug Administration (FDA) maintains a list of over 3000 ingredients in its data base "Everything Added to Food in the United States", many of which we use at home every day (e.g., sugar, baking soda, salt, vanilla, yeast, spices and colors). FDA Let us look at emulsifiers.

Emulsifiers

Definition - molecules or chemicals that help maintain a food's even mixture of two or more non mixable foods such as oil and water

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Laboratory animal data related to emulsifiers

October 18th, 2021

Laboratory animal data related to emulsifiers

Taken directly from Encyclopedia of Food Sciences and Nutrition

In Laboratory animals

In laboratory animals colonic damage can be induced experimentally by administration of therapeutic agents. Dogs administered 2.5 mg/kg of the non-steroidal, anti-inflammatory drug indomethecin orally each day for periods of up to 23 days developed not only gastric and small intestinal ulceration but also scattered hemorrhagic erosions in the colon

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Volume 11, Letter 45 Coronavirus Update 47

October 25th, 2021

North Carolina is back to relative normalcy in most places.

If you have had 2 doses of an mRNA vaccine, you have a very very small risk of a significant hospitalization and therefore death from the Delta variant based on statistics overall.

Being Unvaccinated now is the greatest risk factor for a negative outcome. Advancing age and co morbid disease add layers of risk on top of the vaccination status

Latest numbers google/CDC

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Visual chart for Vaccination verus unvaccination.

 October 25th, 2021

Interesting visual on the CDC webpage showing vaccination versus unvaccinated death risk during the delta surge. All things equal, being unvaccinated caries an 11 X death risk.

Dr. M

 

CDC Webpage

Fluoride

 

November 1st, 2021

What do we know about the state of fluoride need in humans? Do we need it for adequate teeth mineralization? Can we do well without it?

Fluoride is a form of the element fluorine on the periodic table of elements. It is found naturally in rock that over time leaches into water as the primary source of our exposure.

Let us first look at the deficiency state: "In humans, the only clear effect of inadequate fluoride intake is an increased risk of dental caries (tooth decay) for

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Scientific Mechanisms for Caries development

November 1st, 2021

The mechanisms of fluoride oral action suggested by Ullah et al. (13) include the following: reduction in de-mineralization of sound enamel by inhibiting microbial growth and metabolism; enhancement of the remineralization and the recovery of demineralized enamel, and the formation of the fluorapatite mineral phase that provides more resistance to demineralization and acid dissolution following acid production by bacteria; inhibition of enzymes such as reduction of immunoglobulin A protease synthesis; reduction in extracellular polysaccharide production which helps in decreasing bacterial adherence to dental hard tissues.

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Coronavirus Update 45

September 27th, 2021

Wave four is over in our clinic as our test positivity rate has plummeted from the 30% range to less than 5%. We had a four week run of high volume COVID incidence with minimal moderate to almost no severe disease in kids. This is a blessing as the delta variant was a question mark for a little while there.

The best answer to slowing down the pandemic remains vaccination as we are now living in a world where hospitals have been overwhelmed leaving ICU beds unavailable. This is not just a covid unvaccinated person problem as I have had some people tell me.

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    Volume 11, Letter 41

September 27th, 2021

Coronavirus Update 45

The 4th wave appears over in North Carolina.

If you have had 2 doses of an mRNA vaccine, you have a very very small risk of a significant hospitalization and almost no chance of death from the Delta variant based on statistics overall.

Being Unvaccinated now is the greatest risk factor for a negative outcome. Advancing age and co morbid disease add layers of risk on top of the vaccination status

Read more ...